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hisZ [2019-03-30 18:21:38]
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hisZ [2019-03-30 18:21:38]

histidyl-tRNA synthetase
locus
BSU34930
pI
5.15
mw
43.34 kDa
protein length
391 aa Sequence Blast
gene length
1176 bp Sequence Blast
function
translation
product
histidyl-tRNA synthetase
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases]

    • Gene

    Coordinates
    3,588,185 → 3,589,360

    The protein

    Protein family

  • HisZ subfamily (according to Swiss-Prot)

    • Structure

  • [PDB|3OD1] (from B. halodurans, 57% identity)

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|E8FD92F48BE16F87D7481262F4E49003A78DE78F|hisZ]-[gene|183C8B4F28E601D670B3D997D333AF2B5C4A4759|hisG]-[gene|03274B80B2DFE0A2939981B0E0CB8C34A9B0B102|hisD]-[gene|88ED20DFEBD5D7B985F99D4494142FBA699A1E91|hisB]-[gene|DEB3122A3EA36545759FAA6F86F71F971CA5F011|hisH]-[gene|148F0C7983250F50676D234DB713E532AA55DDBF|hisA]-[gene|C22C15754859B2510E52622E6A5DFAF97A7AD4E5|hisF]-[gene|5C84CA2A9E22173E144F519389F545F107A267D9|hisI]
    description
    [Pubmed|12107147]

    regulatory mechanism

  • [protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR]: regulation, [pubmed|30355672], in [regulon|F4097349A563503468A2A14F062AEAC532C7917A|YlxR regulon]

    • regulation

  • expression during spore [SW|germination] is strongly reduced under conditions of osmotic stress [Pubmed|27766092]
  • expression depends on functional [protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR] [pubmed|30355672]
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    Biological materials

    Mutant

  • BKE34930 (Δ[gene|E8FD92F48BE16F87D7481262F4E49003A78DE78F|hisZ]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE34930 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCAACCCGAGCACCTCCG, downstream forward: _UP4_CAAAATGGGTAAGTTACTCA
  • BKK34930 (Δ[gene|E8FD92F48BE16F87D7481262F4E49003A78DE78F|hisZ]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK34930 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCAACCCGAGCACCTCCG, downstream forward: _UP4_CAAAATGGGTAAGTTACTCA

    • References

  • 12107147,27766092,30355672